Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.1
USERS' SCORE
Good
Based on 5 Reviews
8.3
Supplement Facts
Serving Size: 1 Soft Gel
Amount Per Serving
%DV
Vitamin D (as cholecalciferol)
100 mcg (4,000 IU)
500%
Top Medical Research Studies
7
We aimed to explore the connection between Vitamin D levels and excessive daytime sleepiness in patients diagnosed with obstructive sleep apnea (OSA). In this study, we analyzed serum Vitamin D levels in a group of newly diagnosed OSA patients, dividing them into two categories: those who experienced excessive daytime sleepiness (EDS) and those who did not.
Our findings indicated that patients with EDS had significantly lower levels of Vitamin D compared to their non-somnolent counterparts. The study showed that lower Vitamin D levels correlated with higher apnea-hypopnea indices (AHI) and lower oxyhemoglobin saturation during sleep. This suggests that sleep-related hypoxia may impact Vitamin D status and contribute to sleepiness.
Moreover, our analysis indicated that lower Vitamin D levels were independent predictors of EDS. This further emphasizes the potential role of Vitamin D in managing sleep quality for these patients. In summary, our study highlights an important association between Vitamin D levels and daytime sleepiness in people with sleep apnea, suggesting that improving Vitamin D status could be beneficial for managing EDS in these individuals.
Our findings indicated that patients with EDS had significantly lower levels of Vitamin D compared to their non-somnolent counterparts. The study showed that lower Vitamin D levels correlated with higher apnea-hypopnea indices (AHI) and lower oxyhemoglobin saturation during sleep. This suggests that sleep-related hypoxia may impact Vitamin D status and contribute to sleepiness.
Moreover, our analysis indicated that lower Vitamin D levels were independent predictors of EDS. This further emphasizes the potential role of Vitamin D in managing sleep quality for these patients. In summary, our study highlights an important association between Vitamin D levels and daytime sleepiness in people with sleep apnea, suggesting that improving Vitamin D status could be beneficial for managing EDS in these individuals.
7
We explored the connection between vitamin D levels and obstructive sleep apnea (OSA) severity in a group of 262 adults who were diagnosed with OSA through polysomnography (a type of sleep study). Our aim was to understand if vitamin D deficiency could influence the severity of sleep apnea symptoms, particularly given the growing evidence linking these two health issues.
In our findings, we observed that 63% of participants had low vitamin D levels, which were associated with increased severity of OSA. The results showed a negative correlation between vitamin D levels and key sleep parameters, meaning that lower vitamin D was linked to worse apnea-hypopnea indices, which measure the frequency of breathing interruptions.
Notably, when we adjusted for various factors like age, sex, and body mass index, our analysis revealed that individuals with higher vitamin D levels had lower chances of experiencing severe OSA. Conversely, those with vitamin D deficiency were nearly three times more likely to have severe symptoms, particularly in individuals over 50 or those categorized as obese.
This study suggests that maintaining adequate vitamin D levels might be important in managing OSA severity. However, it’s essential to note that we did not specifically examine the effects of vitamin D treatment, so more research is needed to determine whether increasing vitamin D can effectively improve sleep apnea outcomes.
Overall, our work highlights the potential role of vitamin D as a modifiable factor in the complex management of obstructive sleep apnea and its symptoms.
In our findings, we observed that 63% of participants had low vitamin D levels, which were associated with increased severity of OSA. The results showed a negative correlation between vitamin D levels and key sleep parameters, meaning that lower vitamin D was linked to worse apnea-hypopnea indices, which measure the frequency of breathing interruptions.
Notably, when we adjusted for various factors like age, sex, and body mass index, our analysis revealed that individuals with higher vitamin D levels had lower chances of experiencing severe OSA. Conversely, those with vitamin D deficiency were nearly three times more likely to have severe symptoms, particularly in individuals over 50 or those categorized as obese.
This study suggests that maintaining adequate vitamin D levels might be important in managing OSA severity. However, it’s essential to note that we did not specifically examine the effects of vitamin D treatment, so more research is needed to determine whether increasing vitamin D can effectively improve sleep apnea outcomes.
Overall, our work highlights the potential role of vitamin D as a modifiable factor in the complex management of obstructive sleep apnea and its symptoms.
7
We delved into the intriguing link between vitamin D deficiency and obstructive sleep apnea (OSA). Our investigation revealed that many individuals with OSA also struggle with low vitamin D levels, no matter where they are located around the globe. This finding suggests that there may be underlying factors contributing to vitamin D deficiency beyond just insufficient sunlight exposure.
Furthermore, we observed that reduced levels of vitamin D might correlate with more severe cases of OSA. This led us to consider whether boosting vitamin D levels through supplementation could serve as a potential treatment for OSA. Notably, some studies pointed out that patients who took vitamin D supplements reported improvements in sleep quality and a decrease in the severity of their OSA symptoms.
We proposed several potential mechanisms for how vitamin D might influence OSA. These included its role in reducing inflammation and oxidative stress, improving immune function, affecting muscle function, and even involving genetic factors related to vitamin D receptors. However, we underline the need for further research to better understand these connections and to figure out the best dosages and treatment durations for vitamin D supplementation.
Furthermore, we observed that reduced levels of vitamin D might correlate with more severe cases of OSA. This led us to consider whether boosting vitamin D levels through supplementation could serve as a potential treatment for OSA. Notably, some studies pointed out that patients who took vitamin D supplements reported improvements in sleep quality and a decrease in the severity of their OSA symptoms.
We proposed several potential mechanisms for how vitamin D might influence OSA. These included its role in reducing inflammation and oxidative stress, improving immune function, affecting muscle function, and even involving genetic factors related to vitamin D receptors. However, we underline the need for further research to better understand these connections and to figure out the best dosages and treatment durations for vitamin D supplementation.
Most Useful Reviews
9
Improved sleep quality
The quality is high, and the ingredients listed are accurate. My overall feeling has improved, and I’ve noticed enhancements in my immunity and sleep. The dosage is clearly described, and the tablets are easy to absorb. The packaging is convenient and offers protection from sunlight. I truly appreciate this product.
8
Enhanced well-being
The quality is exceptional, with ingredients as per the description. My overall feeling has improved, alongside my immunity and sleep quality. The dosage is detailed appropriately. The tablets are easily digestible, and the packaging is practical and sunproof. I genuinely like this product.
8
Improved mood
All women over 40 should consider taking vitamin D3. It stimulates the functions of various body systems, such as the immune and nervous systems, aids in restoring strength, promotes healthy sleep, and enhances mood.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.1
- All Researches
9.5
We embarked on an intriguing study to see how an eight-week weight loss and lifestyle intervention could influence vitamin D levels in men suffering from obstructive sleep apnea (OSA). Our group of 89 men was split into two; one group received usual care, while the second group engaged in the lifestyle program alongside their standard treatment.
After this intervention, we observed some promising results regarding vitamin D levels. Specifically, the intervention group showed a significant increase in serum 25-hydroxyvitamin D (25(OH)D) levels, with improvements noted at both the end of the 8 weeks and six months later. Indeed, their vitamin D deficiency was potentially resolved.
Moreover, we found that these higher vitamin D levels correlated with better sleep quality, as evidenced by increased sleep efficiency and improvements in several sleep metrics, such as the apnea-hypopnea index (AHI) and oxygen desaturation index. Additionally, body composition measurements, including fat mass, also showed positive changes.
In conclusion, our findings suggest that a coordinated approach combining weight loss and lifestyle changes can be beneficial not just for vitamin D status, but also for overall health aspects related to obstructive sleep apnea.
After this intervention, we observed some promising results regarding vitamin D levels. Specifically, the intervention group showed a significant increase in serum 25-hydroxyvitamin D (25(OH)D) levels, with improvements noted at both the end of the 8 weeks and six months later. Indeed, their vitamin D deficiency was potentially resolved.
Moreover, we found that these higher vitamin D levels correlated with better sleep quality, as evidenced by increased sleep efficiency and improvements in several sleep metrics, such as the apnea-hypopnea index (AHI) and oxygen desaturation index. Additionally, body composition measurements, including fat mass, also showed positive changes.
In conclusion, our findings suggest that a coordinated approach combining weight loss and lifestyle changes can be beneficial not just for vitamin D status, but also for overall health aspects related to obstructive sleep apnea.
8
We embarked on a large-scale study to understand how vitamin D influences obstructive sleep apnea (OSA), especially in those who are obese. Analyzing data from nearly 445,000 participants from the UK Biobank, we focused on individuals who had no previous diagnosis of OSA. The key outcome was the development of new cases of OSA over an average follow-up of 12 years.
What we found was intriguing: higher serum levels of 25-hydroxyvitamin D, the main form of vitamin D in the bloodstream, were associated with a reduced risk of developing new-onset OSA, particularly in participants struggling with obesity. Those with both a body mass index (BMI) of 25 or higher and waist circumference measurements of 90 cm or more showed a significant inverse relationship. This suggests that those with these characteristics might benefit more from maintaining higher vitamin D levels.
The results indicate that while vitamin D supplementation on its own wasn't tested, our findings certainly highlight its potential role in preventing OSA, particularly in at-risk populations. It's a reminder of the importance of monitoring and maintaining adequate vitamin D levels, especially for those dealing with obesity.
What we found was intriguing: higher serum levels of 25-hydroxyvitamin D, the main form of vitamin D in the bloodstream, were associated with a reduced risk of developing new-onset OSA, particularly in participants struggling with obesity. Those with both a body mass index (BMI) of 25 or higher and waist circumference measurements of 90 cm or more showed a significant inverse relationship. This suggests that those with these characteristics might benefit more from maintaining higher vitamin D levels.
The results indicate that while vitamin D supplementation on its own wasn't tested, our findings certainly highlight its potential role in preventing OSA, particularly in at-risk populations. It's a reminder of the importance of monitoring and maintaining adequate vitamin D levels, especially for those dealing with obesity.
7
We conducted a study aimed at understanding how vitamin D3 might influence obstructive sleep apnea (OSA), particularly in hypertensive, obese patients. The research carefully examined the potential benefits of combining vitamin D3 with a medication called Dapagliflozin, a type of SGLT-2 inhibitor known for its additional cardiovascular advantages.
Over 16 weeks, participants were divided into four groups: those receiving Dapagliflozin, those receiving vitamin D3, those receiving both treatments, and a control group that received no treatment. We looked at a range of health parameters, including weight, blood sugar levels, and quality of life scores, to assess the overall impact of these treatments.
Our findings revealed positive outcomes from using vitamin D3 alongside SGLT-2 inhibitors, suggesting that this combination therapy could help improve cardiac and metabolic health, as well as quality of life in patients struggling with OSA. However, we acknowledged the need for further studies to isolate the specific effects of vitamin D on sleep apnea independently from the benefits provided by the medication.
Over 16 weeks, participants were divided into four groups: those receiving Dapagliflozin, those receiving vitamin D3, those receiving both treatments, and a control group that received no treatment. We looked at a range of health parameters, including weight, blood sugar levels, and quality of life scores, to assess the overall impact of these treatments.
Our findings revealed positive outcomes from using vitamin D3 alongside SGLT-2 inhibitors, suggesting that this combination therapy could help improve cardiac and metabolic health, as well as quality of life in patients struggling with OSA. However, we acknowledged the need for further studies to isolate the specific effects of vitamin D on sleep apnea independently from the benefits provided by the medication.
7
We aimed to explore the connection between Vitamin D levels and excessive daytime sleepiness in patients diagnosed with obstructive sleep apnea (OSA). In this study, we analyzed serum Vitamin D levels in a group of newly diagnosed OSA patients, dividing them into two categories: those who experienced excessive daytime sleepiness (EDS) and those who did not.
Our findings indicated that patients with EDS had significantly lower levels of Vitamin D compared to their non-somnolent counterparts. The study showed that lower Vitamin D levels correlated with higher apnea-hypopnea indices (AHI) and lower oxyhemoglobin saturation during sleep. This suggests that sleep-related hypoxia may impact Vitamin D status and contribute to sleepiness.
Moreover, our analysis indicated that lower Vitamin D levels were independent predictors of EDS. This further emphasizes the potential role of Vitamin D in managing sleep quality for these patients. In summary, our study highlights an important association between Vitamin D levels and daytime sleepiness in people with sleep apnea, suggesting that improving Vitamin D status could be beneficial for managing EDS in these individuals.
Our findings indicated that patients with EDS had significantly lower levels of Vitamin D compared to their non-somnolent counterparts. The study showed that lower Vitamin D levels correlated with higher apnea-hypopnea indices (AHI) and lower oxyhemoglobin saturation during sleep. This suggests that sleep-related hypoxia may impact Vitamin D status and contribute to sleepiness.
Moreover, our analysis indicated that lower Vitamin D levels were independent predictors of EDS. This further emphasizes the potential role of Vitamin D in managing sleep quality for these patients. In summary, our study highlights an important association between Vitamin D levels and daytime sleepiness in people with sleep apnea, suggesting that improving Vitamin D status could be beneficial for managing EDS in these individuals.
7
We delved into the intriguing link between vitamin D deficiency and obstructive sleep apnea (OSA). Our investigation revealed that many individuals with OSA also struggle with low vitamin D levels, no matter where they are located around the globe. This finding suggests that there may be underlying factors contributing to vitamin D deficiency beyond just insufficient sunlight exposure.
Furthermore, we observed that reduced levels of vitamin D might correlate with more severe cases of OSA. This led us to consider whether boosting vitamin D levels through supplementation could serve as a potential treatment for OSA. Notably, some studies pointed out that patients who took vitamin D supplements reported improvements in sleep quality and a decrease in the severity of their OSA symptoms.
We proposed several potential mechanisms for how vitamin D might influence OSA. These included its role in reducing inflammation and oxidative stress, improving immune function, affecting muscle function, and even involving genetic factors related to vitamin D receptors. However, we underline the need for further research to better understand these connections and to figure out the best dosages and treatment durations for vitamin D supplementation.
Furthermore, we observed that reduced levels of vitamin D might correlate with more severe cases of OSA. This led us to consider whether boosting vitamin D levels through supplementation could serve as a potential treatment for OSA. Notably, some studies pointed out that patients who took vitamin D supplements reported improvements in sleep quality and a decrease in the severity of their OSA symptoms.
We proposed several potential mechanisms for how vitamin D might influence OSA. These included its role in reducing inflammation and oxidative stress, improving immune function, affecting muscle function, and even involving genetic factors related to vitamin D receptors. However, we underline the need for further research to better understand these connections and to figure out the best dosages and treatment durations for vitamin D supplementation.
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved sleep quality
The quality is high, and the ingredients listed are accurate. My overall feeling has improved, and I’ve noticed enhancements in my immunity and sleep. The dosage is clearly described, and the tablets are easy to absorb. The packaging is convenient and offers protection from sunlight. I truly appreciate this product.
8
Enhanced well-being
The quality is exceptional, with ingredients as per the description. My overall feeling has improved, alongside my immunity and sleep quality. The dosage is detailed appropriately. The tablets are easily digestible, and the packaging is practical and sunproof. I genuinely like this product.
8
Improved mood
All women over 40 should consider taking vitamin D3. It stimulates the functions of various body systems, such as the immune and nervous systems, aids in restoring strength, promotes healthy sleep, and enhances mood.
7.5
Less sleepiness
The vitamins are of excellent quality. I take them once daily, and after two weeks, I've noticed their effectiveness - I feel less tired, and my lethargy has disappeared.
7
Increased energy levels
The quality is excellent. My well-being has improved significantly, with noticeable enhancements in my immunity and sleep. The dosage is clearly described, and the tablets are easy to absorb. The packaging is practical and protects from sunlight. I really like this product.
Frequently Asked Questions
7.5
Less sleepiness
The vitamins are of excellent quality. I take them once daily, and after two weeks, I've noticed their effectiveness - I feel less tired, and my lethargy has disappeared.
9
Improved sleep quality
The quality is high, and the ingredients listed are accurate. My overall feeling has improved, and I’ve noticed enhancements in my immunity and sleep. The dosage is clearly described, and the tablets are easy to absorb. The packaging is convenient and offers protection from sunlight. I truly appreciate this product.
8
Enhanced well-being
The quality is exceptional, with ingredients as per the description. My overall feeling has improved, alongside my immunity and sleep quality. The dosage is detailed appropriately. The tablets are easily digestible, and the packaging is practical and sunproof. I genuinely like this product.
8
Improved mood
All women over 40 should consider taking vitamin D3. It stimulates the functions of various body systems, such as the immune and nervous systems, aids in restoring strength, promotes healthy sleep, and enhances mood.
7
Increased energy levels
The quality is excellent. My well-being has improved significantly, with noticeable enhancements in my immunity and sleep. The dosage is clearly described, and the tablets are easy to absorb. The packaging is practical and protects from sunlight. I really like this product.
7
We explored the connection between vitamin D levels and obstructive sleep apnea (OSA) severity in a group of 262 adults who were diagnosed with OSA through polysomnography (a type of sleep study). Our aim was to understand if vitamin D deficiency could influence the severity of sleep apnea symptoms, particularly given the growing evidence linking these two health issues.
In our findings, we observed that 63% of participants had low vitamin D levels, which were associated with increased severity of OSA. The results showed a negative correlation between vitamin D levels and key sleep parameters, meaning that lower vitamin D was linked to worse apnea-hypopnea indices, which measure the frequency of breathing interruptions.
Notably, when we adjusted for various factors like age, sex, and body mass index, our analysis revealed that individuals with higher vitamin D levels had lower chances of experiencing severe OSA. Conversely, those with vitamin D deficiency were nearly three times more likely to have severe symptoms, particularly in individuals over 50 or those categorized as obese.
This study suggests that maintaining adequate vitamin D levels might be important in managing OSA severity. However, it’s essential to note that we did not specifically examine the effects of vitamin D treatment, so more research is needed to determine whether increasing vitamin D can effectively improve sleep apnea outcomes.
Overall, our work highlights the potential role of vitamin D as a modifiable factor in the complex management of obstructive sleep apnea and its symptoms.
In our findings, we observed that 63% of participants had low vitamin D levels, which were associated with increased severity of OSA. The results showed a negative correlation between vitamin D levels and key sleep parameters, meaning that lower vitamin D was linked to worse apnea-hypopnea indices, which measure the frequency of breathing interruptions.
Notably, when we adjusted for various factors like age, sex, and body mass index, our analysis revealed that individuals with higher vitamin D levels had lower chances of experiencing severe OSA. Conversely, those with vitamin D deficiency were nearly three times more likely to have severe symptoms, particularly in individuals over 50 or those categorized as obese.
This study suggests that maintaining adequate vitamin D levels might be important in managing OSA severity. However, it’s essential to note that we did not specifically examine the effects of vitamin D treatment, so more research is needed to determine whether increasing vitamin D can effectively improve sleep apnea outcomes.
Overall, our work highlights the potential role of vitamin D as a modifiable factor in the complex management of obstructive sleep apnea and its symptoms.
9.5
We embarked on an intriguing study to see how an eight-week weight loss and lifestyle intervention could influence vitamin D levels in men suffering from obstructive sleep apnea (OSA). Our group of 89 men was split into two; one group received usual care, while the second group engaged in the lifestyle program alongside their standard treatment.
After this intervention, we observed some promising results regarding vitamin D levels. Specifically, the intervention group showed a significant increase in serum 25-hydroxyvitamin D (25(OH)D) levels, with improvements noted at both the end of the 8 weeks and six months later. Indeed, their vitamin D deficiency was potentially resolved.
Moreover, we found that these higher vitamin D levels correlated with better sleep quality, as evidenced by increased sleep efficiency and improvements in several sleep metrics, such as the apnea-hypopnea index (AHI) and oxygen desaturation index. Additionally, body composition measurements, including fat mass, also showed positive changes.
In conclusion, our findings suggest that a coordinated approach combining weight loss and lifestyle changes can be beneficial not just for vitamin D status, but also for overall health aspects related to obstructive sleep apnea.
After this intervention, we observed some promising results regarding vitamin D levels. Specifically, the intervention group showed a significant increase in serum 25-hydroxyvitamin D (25(OH)D) levels, with improvements noted at both the end of the 8 weeks and six months later. Indeed, their vitamin D deficiency was potentially resolved.
Moreover, we found that these higher vitamin D levels correlated with better sleep quality, as evidenced by increased sleep efficiency and improvements in several sleep metrics, such as the apnea-hypopnea index (AHI) and oxygen desaturation index. Additionally, body composition measurements, including fat mass, also showed positive changes.
In conclusion, our findings suggest that a coordinated approach combining weight loss and lifestyle changes can be beneficial not just for vitamin D status, but also for overall health aspects related to obstructive sleep apnea.
7
We delved into the intriguing link between vitamin D deficiency and obstructive sleep apnea (OSA). Our investigation revealed that many individuals with OSA also struggle with low vitamin D levels, no matter where they are located around the globe. This finding suggests that there may be underlying factors contributing to vitamin D deficiency beyond just insufficient sunlight exposure.
Furthermore, we observed that reduced levels of vitamin D might correlate with more severe cases of OSA. This led us to consider whether boosting vitamin D levels through supplementation could serve as a potential treatment for OSA. Notably, some studies pointed out that patients who took vitamin D supplements reported improvements in sleep quality and a decrease in the severity of their OSA symptoms.
We proposed several potential mechanisms for how vitamin D might influence OSA. These included its role in reducing inflammation and oxidative stress, improving immune function, affecting muscle function, and even involving genetic factors related to vitamin D receptors. However, we underline the need for further research to better understand these connections and to figure out the best dosages and treatment durations for vitamin D supplementation.
Furthermore, we observed that reduced levels of vitamin D might correlate with more severe cases of OSA. This led us to consider whether boosting vitamin D levels through supplementation could serve as a potential treatment for OSA. Notably, some studies pointed out that patients who took vitamin D supplements reported improvements in sleep quality and a decrease in the severity of their OSA symptoms.
We proposed several potential mechanisms for how vitamin D might influence OSA. These included its role in reducing inflammation and oxidative stress, improving immune function, affecting muscle function, and even involving genetic factors related to vitamin D receptors. However, we underline the need for further research to better understand these connections and to figure out the best dosages and treatment durations for vitamin D supplementation.
References
- Loh HH, Tay SP, Koa AJ, Yong MC, Said A, et al. Unveiling the benefits of Vitamin D3 with SGLT-2 inhibitors for hypertensive obese obstructive sleep apnea patients. J Transl Med. 2025;23:296. doi:10.1186/s12967-025-06312-w
- Vázquez-Lorente H, Herrera-Quintana L, Ruiz JR, Amaro-Gahete FJ, Carneiro-Barrera A. Impact of weight loss and lifestyle intervention on vitamin D in men with obstructive sleep apnea: The INTERAPNEA trial. Sleep Med. 2025;128:37. doi:10.1016/j.sleep.2025.01.011
- Archontogeorgis K, Economou NT, Bargiotas P, Nena E, Voulgaris A, et al. Sleepiness and Vitamin D Levels in Patients with Obstructive Sleep Apnea. Healthcare (Basel). 2024;12. doi:10.3390/healthcare12060698
- Yao N, Ma C, Dou R, Shen C, Yuan Y, et al. Exploring the link between vitamin D deficiency and obstructive sleep apnea: A comprehensive review. J Sleep Res. 2024;33:e14166. doi:10.1111/jsr.14166
- Kechribari I, Kontogianni MD, Georgoulis M, Lamprou K, Perraki E, et al. Associations between Vitamin D Status and Polysomnographic Parameters in Adults with Obstructive Sleep Apnea. Life (Basel). 2024;14. doi:10.3390/life14020275
- Zhang Y, Zhang Y, Ye Z, Zhou C, Yang S, et al. Relationship of serum 25-hydroxyvitamin D, obesity with new-onset obstructive sleep apnea. Int J Obes (Lond). 2024;48:218. doi:10.1038/s41366-023-01402-5
- Locci C, Ruiu A, Saderi L, Sotgiu G, Bassu S, et al. Relationships between 25-Hydroxyvitamin D Levels and Obstructive Sleep Apnea Severity in Children: An Observational Study. J Clin Med. 2023;12. doi:10.3390/jcm12031242
